SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases

Autor: Gonzalo Ferreira, Mariana Guirado, Garth L. Nicolson, Florencia Savio, Axel Santander, Luis Sobrevia
Přispěvatelé: Universidad de la República, Pontificia Universidad Católica de Chile, Universidad de Sevilla, Universidade Estadual Paulista (UNESP), University of Queensland, University Medical Center Groningen (UMCG), The Institute for Molecular Medicine
Jazyk: angličtina
Rok vydání: 2021
Předmět:
E
Envelope
Human pathogen
βCoV
Betacoronavirus
medicine.disease_cause
ENac
Epithelial sodium channel
Zika virus
pp1b
Polyproteins 1b
Mycoplasma
ɣCoV
Gammacoronavirus
N
Nucleocapsid
Pregnancy
Pandemic
HCQ
Hydroxychloroquine
TNF-α
Tumor necrosis factor-α
CQ
Chloroquine
M
Membrane
COVID-19
Coronavirus disease 2019
biology
J-H
Jarisch-Herxheimer reactions
Transmission (medicine)
Zika Virus Infection
Reproduction
History
19th Century
Bacterial Infections
Virus
nsp
Nonstructural proteins
Virus Diseases
HI
Herd immunity
Molecular Medicine
δCoV
Deltacoronavirus
Female
Infection
HGT
Horizontal gene transfer
Context (language use)
CoVs
Coronaviruses
IL
Interleukins
Communicable Diseases
History
21st Century
Article
WHO
World Health Organization
RTC
Replicase-transcriptase complex
ARDS
Acute respiratory distress syndrome
DMVs
Double-membrane vesicles
medicine
Humans
Mycoplasma Infections
RdRp
RNA-dependent RNA polymerase
TMPRSS2
Type II transmembrane serine protease
Molecular Biology
ERS
Endoplasmic reticulum
MHC
Major histocompatibility complex
ORF
Open reading frames
pp1a
Polyproteins 1a
ACE2
Angiotensin-converting enzyme 2 receptors
Bacteria
business.industry
SARS-CoV-2
Infant
Newborn
COVID-19
αCoV
Alphacoronavirus
Zika Virus
ZIKV
Zika Virus
History
20th Century
biology.organism_classification
Virology
S
Spike
Infectious Disease Transmission
Vertical
NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells
Communicable disease transmission
ALA
Alpha-lipoic acid
Pregnant Women
Morbidity
business
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biochimica et Biophysica Acta. Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1867(12):166264. ELSEVIER SCIENCE BV
ISSN: 0925-4439
Popis: Made available in DSpace on 2022-04-28T19:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 Agencia Nacional de Investigación e Innovación Comisión Sectorial de Investigación Científica Fondo Nacional de Desarrollo Científico y Tecnológico The molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates. Laboratory of Ion Channels Biological Membranes and Cell Signaling Department of Biophysics Faculty of Medicine Universidad de la República Department of Infectious Diseases Faculty of Medicine Universidad de la República Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaeology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile Department of Physiology Faculty of Pharmacy Universidad de Sevilla Medical School (Faculty of Medicine) São Paulo State University (UNESP) University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland Department of Pathology and Medical Biology University of Groningen University Medical Center Groningen (UMCG) Department of Molecular Pathology The Institute for Molecular Medicine Medical School (Faculty of Medicine) São Paulo State University (UNESP) Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316
Databáze: OpenAIRE
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