Effect of varenicline directly observed therapy versus varenicline self-administered therapy on varenicline adherence and smoking cessation in methadone-maintained smokers: a randomized controlled trial
| Autor: | Yuming Ning, Shadi Nahvi, Tangeria R. Adams, Chenshu Zhang, Julia H. Arnsten |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Methadone maintenance medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment 030508 substance abuse Medicine (miscellaneous) Article law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans 030212 general & internal medicine Varenicline Directly Observed Therapy media_common Smokers business.industry Opioid use disorder Abstinence Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome chemistry Smoking cessation Female Smoking Cessation 0305 other medical science business Methadone medicine.drug |
| Zdroj: | Addiction |
| ISSN: | 1360-0443 |
| Popis: | BACKGROUND AND AIMS Level of adherence to tobacco cessation medication regimens is believed to be causally related to medication effectiveness. This study aimed to evaluate the efficacy of varenicline directly observed therapy (DOT) on varenicline adherence and smoking cessation rates among smokers with opioid use disorder (OUD) receiving methadone treatment. DESIGN Multicenter, parallel-group two-arm randomized controlled trial. SETTING Urban opioid treatment program (OTP) in the Bronx, New York, USA. PARTICIPANTS Daily smokers of ≥ 5 cigarettes/day, interested in quitting (ladder of change score 6-8), in methadone treatment for ≥ 3 months, attending OTP ≥ 3 days/week. Participants' mean age was 49 years, 56% were male, 44% Latino, 30% Black, and they smoked a median of 10 cigarettes/day. INTERVENTIONS Individual, block, random assignment to 12 weeks of varenicline, either directly observed with methadone (DOT, n = 50) or via unsupervised self-administered treatment (SAT, n = 50). MEASUREMENTS The primary outcome was adherence measured by pill count. The secondary outcome was 7-day point prevalence tobacco abstinence verified by expired carbon monoxide (CO) |
| Databáze: | OpenAIRE |
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