Associations between elevated depressive symptoms and substance use, prescription opioid misuse, overdose history, pain, and general health among community pharmacy patients prescribed opioids

Autor: Jennifer L. Brown, Gerald Cochran, M. Aryana Bryan, Elizabeth Charron, T. John Winhusen
Rok vydání: 2022
Předmět:
Zdroj: Subst Abus
ISSN: 1547-0164
0889-7077
DOI: 10.1080/08897077.2022.2060450
Popis: BACKGROUND: Individuals with pain prescribed opioids experience high rates of comorbid depression. The aim of this study was to characterize pain, substance use, and health status as a function of depressive symptom level in individuals filling an opioid prescription at a community pharmacy. METHODS: Participants (N=1,268) filling an opioid prescription enrolled in a study validating a prescription drug monitoring metric completed an online survey assessing sociodemographics, depressive symptoms, substance use, prescription opioid misuse, overdose history, general health, and pain severity and interference. RESULTS: Approximately one-fifth (19.3%) had a positive depression screen. In covariate-adjusted logistic regression analyses, individuals with a positive depression screen were more likely to have moderate/high substance use risk scores for: prescription opioids (AOR=2.06; 95% CI: 1.51-2.79); street opioids (AOR=7.18; 95% CI: 2.57-20.01); cannabis (AOR=2.00; 95% CI: 1.34-3.00); cocaine (AOR=3.46; 95% CI: 1.46-8.22); tobacco (AOR=1.59; 95% CI: 1.18-2.15); methamphetamine (AOR=7.59; 95% CI: 2.58-22.35); prescription stimulants (AOR=2.95; 95% CI: 1.59-5.49); and sedatives (AOR=3.41; 95% CI: 2.43-4.79). Individuals with a positive depression screen were more likely to misuse prescription opioids (AOR=3.46; 95% CI: 2.33-5.15), experience a prior overdose (AOR=2.69; 95% CI: 1.76-4.11), report poorer general health (AOR=.25, 95% CI: .18-.35), and report moderate/severe pain severity (AOR=4.36, 95% CI: 2.80-6.77) and interference (AOR=6.47, 95% CI: 4.08-10.26). CONCLUSIONS: Individuals prescribed opioids with heightened depression were more likely to report other substance use, prescription opioid misuse, prior overdose, greater pain, and poorer health.
Databáze: OpenAIRE
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