CELL THERAPY OF CRITICAL LIMB ISCHEMIA (PROBLEMS AND PROSPECTS)
| Autor: | A V Lokhonina, V V Kungurtsev, S V Lebedev, E B Kleĭmenova, A V Karasev |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Leg
medicine.medical_specialty Neovascularization Pathologic business.industry Stem Cells Cell- and Tissue-Based Therapy General Medicine Critical limb ischemia Critical lower limb ischemia Cell technology Surgery Cell therapy High morbidity Ischemia medicine Animals Humans Therapeutic angiogenesis medicine.symptom Peripheral Artery Diseases Progenitor cell Intensive care medicine business Stem Cell Transplantation |
| Zdroj: | Annals of the Russian academy of medical sciences. 68:33-44 |
| ISSN: | 0869-6047 |
| DOI: | 10.15690/vramn.v68i3.598 |
| Popis: | Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality. Possibility of surgical and conservative treatment of critical limb ischemia almost completely exhausted. Some hopes have arisen due to progress in cell technology. The article provides a critical analysis of pathogenic prerequisites of stem/progenitor cells for the treatment of patients with a critical limb ischemia in detail the basic results of preclinical and clinical studies on the safety and efficacy of cell technology. Unsolved problems and prospects of practical application are also discussed. |
| Databáze: | OpenAIRE |
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