Dissecting miRNA facilitated physiology and function in human breast cancer for therapeutic intervention
| Autor: | S.G. Suma, Niharika, R. Kirtana, Ankan Roy, Sabnam Parbin, Samir Kumar Patra, Priyanka Saha, Dipta Sengupta, Swayamsiddha Kar, Suraj P. Singh, Chahat Kausar, Priyanka Chakraborty, Soumya Dash, Moonmoon Deb, Nibedita Pradhan, Saumen Manna |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Cell signaling Breast Neoplasms Biology 03 medical and health sciences 0302 clinical medicine microRNA medicine Biomarkers Tumor Gene silencing Animals Humans Epigenetics Molecular Targeted Therapy Epigenomics Regulation of gene expression Cancer Disease Management Translation (biology) medicine.disease Cell biology Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Female |
| Zdroj: | Seminars in cancer biology. 72 |
| ISSN: | 1096-3650 |
| Popis: | MicroRNAs (miRNAs) are key epigenomic regulators of biological processes in animals and plants. These small non coding RNAs form a complex networks that regulate cellular function and development. MiRNAs prevent translation by either inactivation or inducing degradation of mRNA, a major concern in post-transcriptional gene regulation. Aberrant regulation of gene expression by miRNAs is frequently observed in cancer. Overexpression of various 'oncomiRs' and silencing of tumor suppressor miRNAs are associated with various types of human cancers, although overall downregulation of miRNA expression is reported as a hallmark of cancer. Modulations of the total pool of cellular miRNA by alteration in genetic and epigenetic factors associated with the biogenesis of miRNA machinery. It also depends on the availability of cellular miRNAs from its store in the organelles which affect tumor development and cancer progression. Here, we have dissected the roles and pathways of various miRNAs during normal cellular and molecular functions as well as during breast cancer progression. Recent research works and prevailing views implicate that there are two major types of miRNAs; (i) intracellular miRNAs and (ii) extracellular miRNAs. Concept, that the functions of intracellular miRNAs are driven by cellular organelles in mammalian cells. Extracellular miRNAs function in cell-cell communication in extracellular spaces and distance cells through circulation. A detailed understanding of organelle driven miRNA function and the precise role of extracellular miRNAs, pre- and post-therapeutic implications of miRNAs in this scenario would open several avenues for further understanding of miRNA function and can be better exploited for the treatment of breast cancers. |
| Databáze: | OpenAIRE |
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