Delayed graft function and chronic allograft nephropathy: diagnostic and prognostic role of neutrophil gelatinase-associated lipocalin

Autor: Valeria Cernaro, Alberto Noto, Valeria Chirico, Chiara Caccamo, Tullio Bertani, Michele Buemi, Giuseppina Pettinato, Antonio Lacquaniti, Domenico Santoro, Paola Salis, Antonio David, Antoine Buemi
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Health
Toxicology and Mutagenesis
Urinary system
Clinical Biochemistry
030232 urology & nephrology
Urology
Delayed Graft Function
Early detection
030204 cardiovascular system & hematology
Biochemistry
Biomarker
chronic allograft nephropathy
delayed graft function
kidney transplantation
long-term graft failure
neutrophil gelatinase associated lipocalin
03 medical and health sciences
0302 clinical medicine
Lipocalin-2
Chronic allograft nephropathy
medicine
Humans
Prospective Studies
Risk factor
Kidney transplantation
Aged
business.industry
Middle Aged
Prognosis
medicine.disease
Kidney Transplantation
Neutrophil gelatinase-associated lipocalin
surgical procedures
operative
ROC Curve
Chronic Disease
Immunology
Biomarker (medicine)
Female
Kidney Diseases
business
Biomarkers
Zdroj: Biomarkers. 21:371-378
ISSN: 1366-5804
1354-750X
DOI: 10.3109/1354750x.2016.1141991
Popis: Context: Available markers are not reliable parameters to early detect kidney injury in transplanted patients.Objective: Examine neutrophil gelatinase associated lipocalin (NGAL) in early detection of delayed graft function (DGF) and as a long-term predictor of graft outcome.Patients and methods: NGAL was evaluated in 124 transplanted patients.Results: Urinary NGAL levels were associated to a 10% (HR: 1.10; 95% CI: 1.04–1.25; p
Databáze: OpenAIRE
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