The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand
| Autor: | Gerard P. McGlacken, Vera M. Foley, Christina M. McSweeney |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Alkylation
Stereochemistry Chemistry Chiral ligand Intermolecular force Sparteine Metals and Alloys Hydrazones Stereoisomerism General Chemistry Ligands Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Materials Chemistry Ceramics and Composites medicine Chirality (chemistry) medicine.drug |
| Zdroj: | Chemical communications (Cambridge, England). 50(94) |
| ISSN: | 1364-548X |
| Popis: | The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol. |
| Databáze: | OpenAIRE |
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