Seroevidence for a High Prevalence of Subclinical Infection With Avian Influenza A(H5N1) Virus Among Workers in a Live-Poultry Market in Indonesia
| Autor: | Yohko K. Shimizu, Aldise Mareta Nastri, Yusuke Takahara, Amelia Sholikhah, Soetjipto, Resti Yudhawati, Hak Hotta, Gatot Soegiarto, Edith Frederika Puruhito, Maria Inge Lusida, Takako Ustumi, Laksmi Wulandari, Adithya Y. R. Candra, Emmanuel Djoko Poetranto, Retno Asih Setyoningrum, Yoshiaki Yamagishi, Anna Lystia Poetranto, Masaoki Yamaoka, Yasuko Mori, Kazufumi Shimizu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030106 microbiology hemagglutination inhibition Biology medicine.disease_cause Antibodies Viral Virus influenza virus HI 03 medical and health sciences Major Articles and Brief Reports 0302 clinical medicine Seroepidemiologic Studies Occupational Exposure Influenza Human medicine Immunology and Allergy Seroprevalence Animals Humans 030212 general & internal medicine Seroconversion Animal Husbandry Asymptomatic Infections seroconversion Subclinical infection Hemagglutination assay Influenza A Virus H5N1 Subtype avian poultry virus diseases H5N1 Hemagglutination Inhibition Tests Virology Influenza A virus subtype H5N1 Titer Infectious Diseases Indonesia Immunology Viruses subclinical infection seroepidemiology Transmission and infection of H5N1 |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 |
| Popis: | Background. In Indonesia, highly pathogenic avian influenza A(H5N1) virus has become endemic in poultry and has caused sporadic deadly infections in human. Since 2012, we have conducted fixed-point surveillance of avian influenza viruses at a live-poultry market in East Java, Indonesia. In this study, we examined the seroprevalence of avian influenza A(H5N1) virus infection among market workers. Methods. Sera were collected from 101 workers in early 2014 and examined for antibody activity against avian A(H5N1) Eurasian lineage virus by a hemagglutination-inhibition (HI) assay. Results. By the HI assay, 84% of the sera tested positive for antibody activity against the avian virus. Further analysis revealed that the average HI titer in 2014 was 2.9-fold higher than in 2012 and that seroconversion occurred in 44% of paired sera (11 of 25) between 2012 and 2014. A medical history survey was performed in 2016; responses to questionnaires indicated that none of workers had had severe acute respiratory illness during 2013. Conclusions. This study provides evidence of a high prevalence of avian A(H5N1) virus infection in 2013 among workers at a live-poultry market. However, because no instances of hospitalizations were reported, we can conclude the virus did not manifest any clinical symptoms in workers. |
| Databáze: | OpenAIRE |
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