A Study to Assess and Improve Adherence to Iron Chelation Therapy in Transfusion-Dependent Thalassemia Patients

Autor:	Supanun Lauhasurayotin, Piti Techavichit, Hansamon Poparn, Krisada Theppornpitak, Kanhatai Chiengthong, Darintr Sosothikul, Bussaba Trakarnsanga
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Iron Overload Younger age Iron Thalassemia Clinical Biochemistry Iron Chelating Agents Benzoates Iron chelation Internal medicine medicine Humans Transfusion dependent thalassemia Chelation therapy Child Genetics (clinical) business.industry Biochemistry (medical) Deferasirox Hematology Iron chelation therapy medicine.disease Chelation Therapy Cross-Sectional Studies Cohort Female business medicine.drug
Zdroj:	Hemoglobin. 45:171-174
ISSN:	1532-432X 0363-0269
DOI:	10.1080/03630269.2021.1934010
Popis:	Transfusion-dependent thalassemia (TDT) patients require regular blood transfusions. The unavoidable consequence is iron overload. Iron chelation therapy is the mainstay of treatment, of which the favorable outcome depends mainly on adherence level. The aim of this study was to assess adherence to iron chelation therapy of TDT patients. A cross-sectional cohort of TDT patients were evaluated on their adherence to chelation therapy using the Thai version of Morisky Medication Adherence Scales (MMAS-8). A total of 70 patients (38 males, 32 females), with a median age of 10 years, were enrolled in the study. Sixteen patients (22.9%) and 54 patients (77.1%) were classified as high and medium-low adherence level groups. The raised serum ferritin value for 6 months previous to enrollment in the high adherence level group is lower than the medium-low adherence level group (276.4 vs. 413.0 ng/mL, p = 0.034, respectively). Factors impacted high adherence to iron chelation including younger age (p = 0.015) and deferasirox (DFX) administration (p = 0.025). The body weight and height in both groups were not statistically different. The most common obstacle to adherence was forgetfulness. The Thai version of MMAS-8 is a practical tool for evaluating adherence to chelation therapy in TDT patients. High adherence level of patients correlates with more controlled serum ferritin level. The younger age and once-daily dose chelation therapy are associated with better adherence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736b97afc29cc2998ff99b2769acf804 https://doi.org/10.1080/03630269.2021.1934010 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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