A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia
| Autor: | Shitij Kapur, A. Kecojevic, Douglas Hussey, Ralph Lewis, Nicholaas Paul L.G. Verhoeff, Robert B. Zipursky, J. Tauscher, Jeffrey H. Meyer |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Postmortem studies Fluorine Radioisotopes Neuroscience (miscellaneous) Contrast Media Setoperone Pyrimidinones computer.software_genre Statistical parametric mapping chemistry.chemical_compound Voxel medicine Humans Radiology Nuclear Medicine and imaging Receptor Serotonin 5-HT2A Psychiatric Status Rating Scales Analysis of Variance medicine.diagnostic_test business.industry Age Factors Binding potential Brain medicine.disease Psychiatry and Mental health chemistry Positron emission tomography Schizophrenia Case-Control Studies Receptors Serotonin Female Schizophrenic Psychology Analysis of variance Serotonin Antagonists Psychology Nuclear medicine business computer Tomography Emission-Computed |
| Zdroj: | Psychiatry research. 99(3) |
| ISSN: | 0165-1781 |
| Popis: | Several postmortem studies have reported regionally localized decreases in serotonin(2A) receptors (5-HT(2A)R) in schizophrenia. This was not confirmed by two recent [18F]setoperone positron emission tomography (PET) studies. In these two studies relatively large regions of interest (ROIs) were used; hence, 5-HT(2A)R changes may have been missed in some brain areas. Therefore, data from one study were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping (SPM). We also used this method to examine the relationship between 5-HT(2A)R binding potential (BP) and five PANSS-derived factors: negative, positive, activation, dysphoric and autistic preoccupation. Thirteen schizophrenic patients (10 antipsychotic-naive, 3 antipsychotic-free; 11 M, 2 F; age 31+/-7 years) and 35 age-matched control subjects (15 M, 20 F; age 30+/-7 years) were scanned. The 5-HT(2A)R BP was determined for each voxel using the pseudoequilibrium ratio method on PET data obtained between 65 and 90 min after [18F]setoperone bolus injection. The resulting parametric 5-HT(2A)R BP images were spatially normalized using a ligand specific template. Analyses of covariance were done using SPM99 with age as covariate. In tests for the effect of schizophrenia and for partial correlations between 5-HT(2A)R BP and the five factors, corrected P values |
| Databáze: | OpenAIRE |
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