| Autor: |
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure S4. Activation of Stat3/Myc signaling is specific to Ptenpc-/-; Trp53pc-/-prostate and leads to stromal expansion. (A) H&E analysis of prostates from all studied genotypes reveals massive stromal expansion after co-deletion of Pten and Trp53. IHC analysis confirms stromal pStat3/ Myc activation specifically in Ptenpc-/-; Trp53pc-/- prostate. Note that pAkt activation is restricted to gland, consistent with triggering paracrine Il6/Stat3/Myc activation. Scale Bars, 100 μm. (B) Pten is present in the stroma of Ptenpc-/-; Trp53pc-/- prostates confirming that the expansion of stroma is not driven by spurious Pten/Trp53 recombination. (C) Proliferation in the Ptenpc-/- glands correlates with Akt activation, in contrast to Ptenpc-/-; Trp53pc-/- glands, where it correlates with Stat3/ Myc staining. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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