Psammaceratin A: A Cytotoxic Psammaplysin Dimer Featuring an Unprecedented (2Z,3Z)-2,3-Bis(aminomethylene)succinamide Backbone from the Red Sea Sponge Pseudoceratina arabica
| Autor: | Hani Z. Asfour, Lamiaa A. Shaala, Diaa T. A. Youssef |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aquatic Organisms
Pseudoceratina arabica QH301-705.5 Stereochemistry Dimer psammaceratin A Pharmaceutical Science Antineoplastic Agents 01 natural sciences High-performance liquid chromatography Article Red Sea sponge HeLa Structure-Activity Relationship chemistry.chemical_compound psammaplysin A Drug Discovery Animals Humans Moiety Cytotoxic T cell Biology (General) Indian Ocean Pharmacology Toxicology and Pharmaceutics (miscellaneous) biology 010405 organic chemistry Succinates biology.organism_classification Amides Porifera 0104 chemical sciences cell lines’ growth inhibition 010404 medicinal & biomolecular chemistry Sponge chemistry marine alkaloids Growth inhibition psammaplysin dimer HeLa Cells |
| Zdroj: | Marine Drugs Volume 19 Issue 8 Marine Drugs, Vol 19, Iss 433, p 433 (2021) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md19080433 |
| Popis: | Bioassay-guided partition of the extract of the Red Sea sponge Pseudoceratina arabica and HPLC purification of the active fraction gave a psammaplysin dimer, psammaceratin A (1), along with psammaplysin A (2). The dimer comprises two units of psammaplysin A (2) connected via the terminal amines with an unprecedented (2Z,3Z)-2,3-bis(aminomethylene)succinamide moiety, and it represents the first dimer to be identified among the psammaplysin family. Data from 1D- and 2D-NMR and HRMS supported the chemical structures of the compounds. Psammaceratin A (1) and psammaplysin A (2) exhibited significant growth inhibition of HCT 116, HeLa, and MBA-MB-231 cells down to 3.1 μM. |
| Databáze: | OpenAIRE |
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