URINARY IL-6 IS ELEVATED IN PATIENTS WITH UROLITHIASIS
| Autor: | Eunhee Park, Lyric Santiago, Gary C. Bellman, Pramod M. Lad, Eugene Rhee |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
biology Interleukin-6 business.industry Urinary system medicine.medical_treatment Urology Interleukin Alpha (ethology) Gastroenterology Pathogenesis Endocrinology Cytokine Internal medicine Cystitis biology.protein Humans Medicine Urinary Calculi In patient business Interleukin 6 Beta (finance) Interleukin-1 |
| Zdroj: | The Journal of Urology. :2284-2288 |
| ISSN: | 0022-5347 |
| DOI: | 10.1097/00005392-199812010-00101 |
| Popis: | To evaluate the possible role of cytokines interleukin (IL)-1beta, IL-1alpha and IL-6 in patients with urolithiasis.Fifty-six patients currently with stone disease, 63 patients with bacterial cystitis, and 66 normal individuals were evaluated for urinary IL-1alpha, IL-1beta and IL-6. Clean catch urine samples were obtained and evaluated for cytokine levels using enzyme immunoassays for the respective cytokines. Statistical analysis of the results was carried out using the Kruskal-Wallis test followed by Newman-Keuls test and the chi-squared test.The patients with stone disease had significant elevations in IL-6 (p value10(-7)) relative to normal subjects. The levels of IL-6 in stone patients were lower than those of patients with bacterial cystitis. Neither IL-1beta nor IL-1alpha was elevated in stone patients relative to normals. By contrast, bacterial cystitis patients showed significant elevations in all three cytokines relative to normal subjects. Chi-squared analysis confirmed that stone patients had elevated IL-6 without elevation in either IL-1alpha or IL-1beta relative to normal subjects.Stone patients show significant elevations in IL-6 without marked increases in either IL-1beta or alpha relative to normal subjects. This elevation in IL-6 is not from infection as is seen in bacterial cystitis subjects. The elevation in IL-6 may be useful in the understanding of the pathogenesis of urolithiasis or as a potential marker for stone disease and we are currently investigating these possibilities. |
| Databáze: | OpenAIRE |
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