EEG correlates of a mental arithmetic task in patients with first episode schizophrenia and schizoaffective disorder
| Autor: | Ondrej Fiala, Valeria Strelets, Yuliya Zaytseva, Isaac Ya. Gurovich, Zhanna Garakh, Alexandra Kapranova, Jiri Horacek, Alexander Shmukler |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Rest Schizoaffective disorder Audiology Electroencephalography Task (project management) Young Adult Cognition Physiology (medical) Task Performance and Analysis medicine Humans In patient Theta Rhythm Psychiatry First episode Brain Mapping Resting state fMRI medicine.diagnostic_test Middle Aged medicine.disease Sensory Systems Alpha Rhythm Psychotic Disorders Neurology Schizophrenia Case-Control Studies Female Neurology (clinical) Beta Rhythm Psychology Mathematics |
| Zdroj: | Clinical Neurophysiology. 126:2090-2098 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2014.12.031 |
| Popis: | Objective To evaluate the spectral power of the cortical bands in patients with first episode schizophrenia and schizoaffective disorder at rest and during the performance of a mental arithmetic task. Methods We analyzed EEG spectral power (SP) in the resting state and subsequently while counting down from 200 in steps of 7, in 32 first episode schizophrenia patients (SZ), 32 patients with first episode schizoaffective disorder (SA) and healthy controls (HC, n =40). Behavioral parameters such as accuracy and counting speed were also evaluated. Results Both SZ and SA patients were slower in counting than HC, no difference was obtained in the accuracy and counting speed in the patient groups. In the resting state patients showed elevated midline theta power, off-midline anterior beta 2 power and decreased central/posterior alpha power. The SA group occupied an intermediate position between the schizophrenia patients and controls. In task performance patients lacked a typical increase of midline theta , left anterior beta 2 , and anterior gamma power; however, schizoaffective patients demonstrated a growing trend of power in the gamma band in left anterior off-midline sites similar to HC. Moreover, alpha power was less inhibited in schizoaffective patients and more pronounced in schizophrenia patients indicating distinct inhibitory mechanisms in these psychotic disorders. Conclusions Patients with SA demonstrate less alteration in the spectral power of bands at rest than SZ, and present spectral power changes during cognitive task performance close to the controls. Significance Our study contributes to the present evidence on the neurophysiological distinction between schizophrenia and schizoaffective disorder. |
| Databáze: | OpenAIRE |
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