Successful chemotherapeutic treatment for metastatic littoral cell angioma

Autor: Kenji Tsuchihashi, Kenichi Kohashi, Yoshinao Oda, Jun Odawara, Yoshihiko Maehara, Hiroshi Ariyama, Shinji Itoh, Nobuhiro Tsuruta, Koichi Akashi, Tomoyasu Yoshihiro, Norifumi Harimoto, Kenta Nio, Goro Doi, Eishi Baba, Shinji Shimoda, Hitoshi Kusaba, Kotoe Takayoshi
Rok vydání: 2018
Předmět:
genetic structures
Biopsy
medicine.medical_treatment
Treatment outcome
etoposide
hemophagocytic syndrome
0302 clinical medicine
Therapeutic strategy
Biopsy methods
Cytotoxins
Liver Neoplasms
littoral cell angioma
General Medicine
Middle Aged
Immunohistochemistry
fluoro-deoxyglucose-positron emission tomography
Treatment Outcome
Liver
Vincristine
030220 oncology & carcinogenesis
Splenectomy
Female
030211 gastroenterology & hepatology
Radiology
Hemangioma
Liver pathology
Research Article
medicine.medical_specialty
Paclitaxel
MEDLINE
03 medical and health sciences
Fluorodeoxyglucose F18
parasitic diseases
medicine
Humans
Clinical Case Report
Chemotherapy
business.industry
Splenic Neoplasms
medicine.disease
Antineoplastic Agents
Phytogenic
eye diseases
Littoral cell angioma
Positron-Emission Tomography
sense organs
Radiopharmaceuticals
Tomography
X-Ray Computed
business
Zdroj: Medicine
ISSN: 0025-7974
DOI: 10.1097/md.0000000000010378
Popis: Rationale: Metastatic littoral cell angioma (LCA) is extremely rare. No standard therapeutic strategy has been established, and the impact of chemotherapy has not yet been evaluated. Patient concerns: A 61-year-old woman was admitted because of bicytopenia. She had a splenectomy for LCA of the spleen 10 years earlier. Bone marrow aspiration was normal, and a computed tomography (CT) scan showed hepatomegaly with multiple liver tumors. Diagnoses: Liver biopsy samples showed macrophage-like cell infiltration in the hepatic sinusoids. Metastatic LCA was diagnosed based on immunohistochemistry, imaging tests, and the clinical course. Interventions: Immunosuppressive agents, such as prednisolone and cyclosporine, were ineffective. Next, cytotoxic agents, such as etoposide, paclitaxel, and vincristine, were administered. Outcomes: Cytotoxic agents showed a prominent effect against LCA. CT showed improvement of the hepatomegaly, and fluoro-deoxyglucose (FDG) uptake decreased markedly at a follow-up FDG- positron emission tomography (PET) scan. Lessons: Chemotherapeutic treatment based on hemophagocytic syndrome or angiosarcoma might have anti-tumor activity against metastatic LCA. Analysis of the molecular characteristics of this tumor is needed to develop better treatment options.
Databáze: OpenAIRE
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