The journey of herpesvirus capsids and genomes to the host cell nucleus
| Autor: | Katinka Döhner, Manutea Christophe Serrero, Beate Sodeik, Angela D. A. Cornelius |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell Nucleus
0303 health sciences Nucleoplasm viruses 030302 biochemistry & molecular biology biochemical phenomena metabolism and nutrition Biology Genome Cell biology 03 medical and health sciences Capsid Cytosol Microtubule Centrosome Virology Simplexvirus Capsid Proteins Nucleoporin Nuclear pore Host cell nucleus 030304 developmental biology |
| Zdroj: | Current opinion in virology. 50 |
| ISSN: | 1879-6265 |
| Popis: | Starting a herpesviral infection is a steeplechase across membranes, cytosol, and nuclear envelopes and against antiviral defence mechanisms. Here, we highlight recent insights on capsid stabilization at the portals during assembly, early capsid-host interactions ensuring nuclear targeting of incoming capsids, and genome uncoating. After fusion with a host membrane, incoming capsids recruit microtubule motors for traveling to the centrosome, and by unknown mechanisms get forward towards the nucleus. The interaction of capsid-associated tegument proteins with nucleoporins orients the capsid portal towards the nuclear pore, and presumably after removal of the portal caps the genomes that have been packaged under pressure can be injected into the nucleoplasm for transcription and replication. Some cell types disarm the incoming capsids or silence the incoming genomes to reduce the likelihood of infection. |
| Databáze: | OpenAIRE |
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