Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity
| Autor: | Christoph Beglinger, Valentine Bordier, Frank Senner, Götz Schlotterbeck, Bettina K. Wölnerhanssen, Fabienne Teysseire, Anne Christin Meyer-Gerspach |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty obesity Absorption (skin) Erythritol natural sweeteners Xylitol Article Glucose absorption chemistry.chemical_compound Internal medicine medicine Ingestion Humans In patient TX341-641 Nutrition and Dietetics business.industry Nutrition. Foods and food supply Area under the curve food and beverages medicine.disease Obesity Absorption Physiological carbohydrates (lipids) xylitol Endocrinology Glucose glucose absorption chemistry 3-OMG Female business erythritol Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 3950, p 3950 (2021) Nutrients Volume 13 Issue 11 |
| ISSN: | 2072-6643 |
| Popis: | In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal glucose absorption was assessed during an oral glucose tolerance test with 3-Ortho-methyl-glucose (3-OMG). The effect of xylitol or erythritol intake on the area under the curve for 3-OMG concentration was not significant. Neither the time (pre or post intervention), nor the group (control, xylitol, or erythritol), nor the time-by-group interaction effects were significant (p = 0.829, p = 0.821, and p = 0.572, respectively). Therefore, our results show that a chronic intake of the natural sweeteners xylitol and erythritol does not affect intestinal glucose absorption in humans with obesity. |
| Databáze: | OpenAIRE |
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