Prognostic factors and the role of pelvic lymphadenectomy in uterine leiomyosarcomas
| Autor: | Bouzaine Hatem, Boujelbene Nadia, Tounsi Nesrine, Zemni Ines, Nawel Abdelwahed, Hechiche Monia, Slimane Maher, Rahel Khaled, Ayadi Mohamed Ali |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:R5-920 030219 obstetrics & reproductive medicine lymph node metastasis business.industry medicine.medical_treatment overall survival uterine sarcomas Lymphadenectomy General Medicine Lymph node metastasis uterine leiomyosarcomas 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Smooth Muscle Tumor medicine Overall survival Original Article Radiology business Pelvic lymphadenectomy lcsh:Medicine (General) |
| Zdroj: | SAGE Open Medicine SAGE Open Medicine, Vol 7 (2019) |
| ISSN: | 2050-3121 |
| Popis: | Objectives: Leiomyosarcomas are relatively rare uterine smooth muscle tumors. Surgery is the most common therapy choice for uterine leiomyosarcomas. However, controversy exists over the appropriate initial surgical management, especially about the role of lymph node sampling. The aim of our study is to analyze the prognostic factors and the role of lymphadenectomy in overall survival and in disease-free survival. Methods: We analyzed retrospectively 31 patients suffering from uterine leiomyosarcomas at Institute of Salah Azaiez during 2000–2014. Demographic and clinical features such as age, menopausal status, stage, tumor size, and management options were examined, and pathological characteristics such as mitotic count, lymphovascular space invasion, and tumor necrosis were evaluated. Results: Out of 31 patients treated for uterine leiomyosarcomas, pelvic lymphadenectomy was done for 18 patients. No para-aortic lymphadenectomy was performed. Median number of resected lymph nodes was 13 ± 7 (range: 3–27). Lymphatic metastasis was observed in 2 out of 18 patients with clinical stage IA and IIIB. The distribution of different variables (age, International Federation of Gynecology and Obstetrics stage, tumor size, mitotic count, and adjuvant treatment) between the group of patients, who had or had not lymphadenectomy done, had no significant difference. The 5-year overall survival and disease-free survival were 61% and 50%, respectively. Clinical stage, presence of lymphovascular space invasion, and lymph nodal dissection were found to be relevant for disease-free survival on univariate analysis. Only age and menopausal status were found to be a prognostic factor for overall survival. Conclusion: Hence, routine lymph node dissection was not generally recommended. Our study demonstrates that lymphadenectomy has a statistically significant effect on disease-free survival but not on overall survival. |
| Databáze: | OpenAIRE |
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