Urine Bile Acids Relate to Glucose Control in Patients with Type 2 Diabetes Mellitus and a Body Mass Index Below 30 kg/m2
| Autor: | Jamshid Alaghband-Zadeh, Carel W. le Roux, Royce P Vincent, David R Taylor, Gemma F. Cross, Sohail Omar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male Proteomics Physiology Type 2 diabetes Overweight Biochemistry Body Mass Index chemistry.chemical_compound Endocrinology Medicine and Health Sciences Glucose homeostasis Liquid Chromatography Spectrometric Identification of Proteins Multidisciplinary Bile acid Chromatographic Techniques Middle Aged Lipids Type 2 Diabetes Sterols Chemistry Physiological Parameters Glycodeoxycholic acid Glycodeoxycholic Acid Blood Chemistry Physical Sciences Medicine Female medicine.symptom Research Article medicine.medical_specialty medicine.drug_class Science Research and Analysis Methods Bile Acids and Salts Excretion Insulin resistance Internal medicine Diabetes Mellitus medicine Humans Obesity Aged Nutrition Glycated Hemoglobin Diabetic Endocrinology business.industry Body Weight Biology and Life Sciences Type 2 Diabetes Mellitus medicine.disease Hormones Diabetes Mellitus Type 2 chemistry Case-Control Studies Metabolic Disorders business |
| Zdroj: | PLoS ONE, Vol 9, Iss 4, p e93540 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0093540 |
| Popis: | Bile acids are important endocrine signalling molecules, modulating glucose homeostasis through activation of cell surface and nuclear receptors. Bile acid metabolism is altered in type 2 diabetes mellitus; however, whether this is of pathogenic consequence is not fully established. In this study urinary bile acid excretion in individuals with type 2 diabetes and matched healthy volunteers was assessed. Urinary bile acid excretion in type 2 diabetes patients was considered in the context of prevailing glycaemia and the patient body mass index. Urine bile acids were measured by liquid chromatography-tandem mass spectrometry, allowing individual quantification of 15 bile acid species. Urinary bile acid excretion in patients with type 2 diabetes who were normal weight (BMI 18.5–24.9 kg/m2) and overweight (BMI 25–29.9 kg/m2) were elevated compared to healthy normal weight volunteers, both p |
| Databáze: | OpenAIRE |
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