Effects of Prenatal Micronutrient Supplementation on Spontaneous Preterm Birth: A Double-Blind Randomized Controlled Trial in China
| Autor: | Yali Zhang, Mary K. Serdula, Rongwei Ye, Nan Li, Zuguo Mei, Aiguo Ren, Hongtian Li, Le Zhang, Jianmeng Liu, Zhiwen Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Epidemiology macromolecular substances Prenatal care Article law.invention Young Adult 03 medical and health sciences Folic Acid 0302 clinical medicine Double-Blind Method Randomized controlled trial Pregnancy law medicine Humans Micronutrients 030212 general & internal medicine 030219 obstetrics & reproductive medicine business.industry Obstetrics medicine.disease Micronutrient Confidence interval Premature birth Relative risk Dietary Supplements Premature Birth Gestation Female business |
| Zdroj: | Am J Epidemiol |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/aje/kwx094 |
| Popis: | In this secondary analysis of data from a double-blind randomized controlled trial carried out in northern China, we aimed to assess the effect of prenatal supplementation with multiple micronutrients (MMN) or iron + folic acid (IFA), versus folic acid (FA) alone, on risk of spontaneous preterm birth (SPB) and the impact of supplementation timing on SPB. A total of 18,775 nulliparous pregnant women enrolled between 2006 and 2009 were randomly assigned to receive daily FA, IFA, or MMN from the period before 20 weeks’ gestation to delivery. The incidences of SPB for women consuming FA, IFA, and MMN were 5.7%, 5.6% and 5.1%, respectively. Compared with women given FA, the relative risks of SPB for those using MMN and IFA were 0.99 (95% confidence interval: 0.85, 1.16) and 0.89 (95% confidence interval: 0.79, 1.05), respectively. SPB incidence in women who started consuming FA, IFA, and MMN before the 12th week of gestation (4.6%, 4.2%, and 3.9%, respectively) was significantly reduced compared with starting supplement use on or after the 12th gestational week (6.9%, 7.2%, and 6.4%, respectively). Starting use of FA, IFA, or MMN supplements before the 12th week of gestation produced a 41%–45% reduction in risk of SPB. Early prenatal enrollment and micronutrient use during the first trimester of pregnancy appeared to be of particular importance for prevention of SPB, regardless of supplement group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|