Epidemiologic factors that predict long-term survival following a diagnosis of epithelial ovarian cancer

Autor: John R. McLaughlin, Shana J. Kim, Steven A. Narod, Anna Ivanova, Barry P. Rosen, Harvey A. Risch, Isabel Fan, Joanne Kotsopoulos
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Cancer Research
Epidemiologic Factors
Epidemiology
medicine.medical_treatment
Disease
0302 clinical medicine
Pregnancy
Medicine
Young adult
Reproductive History
Ovarian Neoplasms
Hazard ratio
Hormone replacement therapy (menopause)
Middle Aged
Prognosis
Adenocarcinoma
Mucinous
3. Good health
Parity
ovarian cancer
030220 oncology & carcinogenesis
Female
reproductive factors
Adult
medicine.medical_specialty
Canada
lifestyle
Hormone Replacement Therapy
03 medical and health sciences
Young Adult
Internal medicine
Humans
Neoplasm Invasiveness
Aged
Neoplasm Staging
hormones
business.industry
medicine.disease
Confidence interval
Cancer registry
Cystadenocarcinoma
Serous
Endometrial Neoplasms
030104 developmental biology
business
Ovarian cancer
Adenocarcinoma
Clear Cell
Follow-Up Studies
Zdroj: British Journal of Cancer
ISSN: 1532-1827
Popis: Background: Various epidemiologic factors have been shown to influence the risk of ovarian cancer development. Given the high fatality associated with this disease, it is of interest to evaluate the association of prediagnostic hormonal, reproductive, and lifestyle exposures with ovarian cancer-specific survival. Methods: We included 1421 patients with invasive epithelial ovarian cancer diagnosed in Ontario, Canada. Clinical information was obtained from medical records and prediagnostic exposure information was collected by telephone interview. Survival status was determined by linkage to the Ontario Cancer Registry. Proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for ovarian cancer-specific mortality associated with each exposure. Analyses were stratified by histologic subtype to further investigate the associations of risk factors on ovarian cancer-specific mortality. Results: After a mean follow-up of 9.48 years (range 0.59–20.32 years), 655 (46%) women had died of ovarian cancer. Parity (ever) was associated with a significant 29% decreased mortality risk compared with nulliparity (HR=0.71; 95% CI 0.54–0.93; P=0.01). There was a borderline significant association between ever use of oestrogen-containing hormone replacement therapy (HRT) and mortality (HR=0.79; 95% CI 0.62–1.01; P=0.06). A history of cigarette smoking was associated with a significant 25% increased risk of death compared with never smoking (HR=1.25; 95% CI 1.01–1.54; P=0.04). Women with a greater cumulative number of ovulatory cycles had a significantly decreased risk of ovarian cancer-specific death (HR=0.63; 95% CI 0.43–0.94; P=0.02). Increasing BMI (kg m−2) 5 years before diagnosis was associated with an increased risk of death (HR=1.17; 95% CI 1.07–1.28; P=0.0007). Other hormonal or lifestyle factors were not significantly associated with ovarian cancer-specific mortality. Conclusions: Parity, ovulatory cycles, smoking, and BMI may affect survival following the diagnosis of ovarian cancer. Whether or not oestrogen-containing HRT use is beneficial for survival requires further evaluation.
Databáze: OpenAIRE
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