Penicillin impregnation on oxygen plasma surface functionalized chitosan/ Antheraea assama silk fibroin: Studies of antibacterial activity and antithrombogenic property
| Autor: | Yogesh B. Chaudhari, A. Choudhury, Sanjeeb Kalita, Jibon Kotoky, Raghuram Kandimalla, Joyanti Chutia, Mojibur R. Khan, Dolly Gogoi |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility Silk Fibroin Penicillin G Sodium Biocompatible Materials Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Chitosan chemistry.chemical_compound Fibrinolytic Agents Bombyx mori Polymer chemistry Animals biology fungi Biomaterial 021001 nanoscience & nanotechnology biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences SILK chemistry Mechanics of Materials Surface modification Fibroins 0210 nano-technology Nuclear chemistry |
| Zdroj: | Materials Science and Engineering: C. 60:475-484 |
| ISSN: | 0928-4931 |
| Popis: | Low temperature plasma can effectively tailor the surface properties of natural polymeric biomaterials according to the need for various biomedical applications. Non-mulberry silk, Antheraea assama silk fibroin (AASF) is a natural polymer having excellent biocompatibility and mechanical strength yet unlike mulberry silk, Bombyx mori silk fibroin, has drawn less interest in biomedical research. In the quest for developing as potential biomaterial, surface functionalization of plasma induced chitosan (Cs) grafted AASF ((AASF/O2-CS)g/O2) yarn is carried out using oxygen (O2) plasma. The (AASF/O2-CS)g/O2 yarn exhibits enhanced antithrombogenic property as well as antimicrobial activity against Gram positive (Bacillus subtilis) and Gram negative (Escherichia coli) bacteria as compared to AASF yarn. Moreover, impregnation of antibiotic drug (penicillin G sodium salt, PEN) on (AASF/O2-CS)g/O2 yarn further improves the observed properties. In-vitro hemolysis assay reveals that O2 plasma treatment and subsequent impregnation of PEN do not affect the hemocompatibility of AASF yarn. The present research findings demonstrate that plasma induced grafting of Cs followed by penicillin impregnation could significantly improve the potential applicability of AASF in the field of surgical research. |
| Databáze: | OpenAIRE |
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