Genetic polymorphisms in Thai neonates with hyperbilirubinemia
| Autor: | Sariya Prachukthum, Saowanee Kajanachumpol, Samart Pakakasama, Daunthida Songdej, Suradej Hongeng, Ampaiwan Chuansumrit, Paneeya Pienvichit, Pracha Nunnarumit |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Bilirubin DNA Mutational Analysis Organic Anion Transporters Gastroenterology chemistry.chemical_compound Risk Factors Internal medicine ABO blood group system Genotype Genetic variation medicine Glucose-6-phosphate dehydrogenase Humans Glucuronosyltransferase Gene Glutathione Transferase Analysis of Variance Chi-Square Distribution Polymorphism Genetic biology business.industry Liver-Specific Organic Anion Transporter 1 Infant Newborn General Medicine Odds ratio DNA Thailand Glucosephosphate Dehydrogenase Deficiency chemistry Case-Control Studies Pediatrics Perinatology and Child Health biology.protein Regression Analysis Female Hyperbilirubinemia Neonatal SLCO1B1 business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 98(7) |
| ISSN: | 1651-2227 |
| Popis: | Aim: Polymorphisms of the UGT1A1 gene, SLCO1B1 gene and GST gene have been associated with significant hyperbilirubinemia. We would like to determine whether the variation of UGT1A1 gene, SLCO1B1 gene and GST gene may play a significant role in neonatal hyperbilirubinemia in Thai infants. Methods: Ninety-one study subjects (hyperbilirubinemic group) and 86 control subjects were studied. Results: The cause of neonatal hyperbilirubinemia could not be identified in 64 infants (70.3%), ABO blood group incompatibility in 14.3% and Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in 8.8%. In the hyperbilirubinemic group, 23 of 91 (25.3%) infants demonstrated variant of UGT1A1 at nucleotides (nt) 211 as compared to 6 of 86 (7%) in the control group (p = 0.001). There were no significant differences between groups in the variants UGT1A1 at nt 686, SLCO1B1 gene at nt 388, 463 and the GST gene. Male infants with G-6-PD deficiency were associated with hyperbilirubinemia (21.2% vs. 4.8% in the control group) with an odds ratio (OR) of 5.37 (p =0.02). The relationship between G-6-PD and variant in UGT1A1 gene at nt 211 could not be determined. Conclusion: Thai infants with variant in the UGT1A1 at nt 211 or with G-6-PD deficiency are at higher risk for developing neonatal hyperbilirubinemia. |
| Databáze: | OpenAIRE |
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