Antibiotics and peptides with agonist and antagonist chemotactic activity
| Autor: | Erhard Gross, Barbara A. Corcoran, Elliott Schiffmann, S. Aswanikumar, Candace B. Pert, John L. Morell |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Agonist
medicine.drug_class Stereochemistry Neutrophils Antibiotics Biophysics Peptide Bacitracin Biochemistry Residue (chemistry) chemistry.chemical_compound Structure-Activity Relationship medicine Humans Amino Acid Sequence Molecular Biology chemistry.chemical_classification Tyrocidine Chemistry Chemotaxis Antagonist Gramicidin Cell Biology Anti-Bacterial Agents Kinetics Oligopeptides medicine.drug |
| Zdroj: | Biochemical and biophysical research communications. 80(2) |
| ISSN: | 0006-291X |
| Popis: | It has been found that the polypeptide antibiotics gramicidin S, tyrocidin and bacitracin, containing Leu-Phe or Ile-Phe sequences, are chemoattractants for neutrophils. Related synthetic pentapeptides containing the sequence Leu-Phe have stronger biological activities, provided the N-terminal residue is acylated. The formylated peptide f-L-Phe-D-Leu-L-Phe-D-Leu-L-Phe is a potent agonist (4 × 10 −9 M) whereas the t-butyloxycarbonyl analog is a good antagonist (8 × 10 −7 M). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|