Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model

Autor: Jae Yeon Kim, Si Hyun Bae, Jong Ho Choi, Seong-Gyu Hwang, Gi Dae Kim, Ji Hye Jun, Soon Koo Baik, Sohae Park, Gi Jin Kim
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2530, p 2530 (2021)
ISSN: 2073-4409
DOI: 10.3390/cells10102530
Popis: Phosphatase of regenerating liver-1 (PRL-1) controls various cellular processes and liver regeneration. However, the roles of PRL-1 in liver regeneration induced by chorionic-plate-derived mesenchymal stem cells (CP-MSCs) transplantation remain unknown. Here, we found that increased PRL-1 expression by CP-MSC transplantation enhanced liver regeneration in a bile duct ligation (BDL) rat model by promoting the migration and proliferation of hepatocytes. Engrafted CP-MSCs promoted liver function via enhanced hepatocyte proliferation through increased PRL-1 expression in vivo and in vitro. Moreover, higher increased expression of PRL-1 regulated CP-MSC migration into BDL-injured rat liver through enhancement of migration-related signals by increasing Rho family proteins. The dual effects of PRL-1 on proliferation of hepatocytes and migration of CP-MSCs were substantially reduced when PRL-1 was silenced with siRNA-PRL-1 treatment. These findings suggest that PRL-1 may serve as a multifunctional enhancer for therapeutic applications of CP-MSC transplantation.
Databáze: OpenAIRE