Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model
Autor: | Jae Yeon Kim, Si Hyun Bae, Jong Ho Choi, Seong-Gyu Hwang, Gi Dae Kim, Ji Hye Jun, Soon Koo Baik, Sohae Park, Gi Jin Kim |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
endocrine system
QH301-705.5 bile duct ligation Placenta phosphatase of regenerating liver-1 Placenta cord banking Mesenchymal Stem Cell Transplantation Article Pregnancy medicine Animals Humans Biology (General) liver regeneration Cell Proliferation Chemistry Bile duct Regeneration (biology) Mesenchymal stem cell Mesenchymal Stem Cells General Medicine Liver regeneration chorionic-plate-derived mesenchymal stem cells Cell biology Rats Transplantation medicine.anatomical_structure Liver Hepatocyte Hepatocytes Female Liver function Bile Ducts hormones hormone substitutes and hormone antagonists |
Zdroj: | Cells Volume 10 Issue 10 Cells, Vol 10, Iss 2530, p 2530 (2021) |
ISSN: | 2073-4409 |
DOI: | 10.3390/cells10102530 |
Popis: | Phosphatase of regenerating liver-1 (PRL-1) controls various cellular processes and liver regeneration. However, the roles of PRL-1 in liver regeneration induced by chorionic-plate-derived mesenchymal stem cells (CP-MSCs) transplantation remain unknown. Here, we found that increased PRL-1 expression by CP-MSC transplantation enhanced liver regeneration in a bile duct ligation (BDL) rat model by promoting the migration and proliferation of hepatocytes. Engrafted CP-MSCs promoted liver function via enhanced hepatocyte proliferation through increased PRL-1 expression in vivo and in vitro. Moreover, higher increased expression of PRL-1 regulated CP-MSC migration into BDL-injured rat liver through enhancement of migration-related signals by increasing Rho family proteins. The dual effects of PRL-1 on proliferation of hepatocytes and migration of CP-MSCs were substantially reduced when PRL-1 was silenced with siRNA-PRL-1 treatment. These findings suggest that PRL-1 may serve as a multifunctional enhancer for therapeutic applications of CP-MSC transplantation. |
Databáze: | OpenAIRE |
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