Relation Between Body Mass Index and Dry Eye Disease: The Japan Public Health Center-Based Prospective Study for the Next Generation
| Autor: | Ryutaro Yamanishi, Kazumasa Yamagishi, Kazuhiko Arima, Manami Inoue, Kenya Yuki, Kiyomi Sakata, Kazuo Tsubota, Taiki Yamaji, Akiko Hanyuda, Miki Uchino, Tadahiro Kato, Satoshi Mizukami, Motoki Iwasaki, Kozo Tanno, Taichi Shimazu, Nobufumi Yasuda, Isao Saito, Atsushi Goto, Norie Sawada, Hiroyasu Iso, Motoko Kawashima, Shoichiro Tsugane |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Logistic regression Body Mass Index Japan Risk Factors Surveys and Questionnaires Prevalence Medicine Humans Prospective Studies Prospective cohort study business.industry Public health Odds ratio Confidence interval Ophthalmology Cross-Sectional Studies Transgender hormone therapy Cohort Dry Eye Syndromes Female Public Health business Body mass index Demography |
| Zdroj: | Eyecontact lens. 47(8) |
| ISSN: | 1542-233X |
| Popis: | Objective To investigate the relation between body mass index (BMI) and dry eye disease (DED). Methods We conducted a cross-sectional questionnaire-based survey in 85,264 Japanese men and women aged 40 to 74 years who participated in the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT Study). Dry eye disease was defined as the presence of severe symptoms or clinical diagnosis. A multivariable logistic regression model was used to estimate the odds ratios (ORs) of DED associated with BMI and their two-sided 95% confidence intervals (CIs). We adjusted for age, cohort area, visual display terminal time, smoking status, alcohol intake, education status, income status, as well as history of hormone replacement therapy for women. Results Prevalence of DED was 23.4% (n = 19,985; 6,289 men, 13,696 women). Higher BMI was correlated with a lower prevalence of DED in a dose-response fashion, with an adjusted OR of DED (95% CI) per 1 kg/m2 increment of BMI of 0.98 (95% CI: 0.97-0.99) for men and 0.97 (95% CI: 0.97-0.98) for women. Conclusions This large population-based study showed an inverse relationship between BMI and prevalence of DED in a Japanese population. Underestimation of DED is warned, especially for participants with high BMI. |
| Databáze: | OpenAIRE |
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