The Location of the Inferior and Superior Temporal Blood Vessels and Interindividual Variability of the Retinal Nerve Fiber Layer Thickness
| Autor: | Jeffrey M. Liebmann, Stella N. Arthur, Robert Ritch, Jennifer A. Salant, Donald C. Hood |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Retinal Ganglion Cells
medicine.medical_specialty genetic structures Retinal Artery Optic Disk Gonioscopy Visual Acuity Nerve fiber layer Optic disk Glaucoma Scanning laser polarimetry Article chemistry.chemical_compound Nerve Fibers Optical coherence tomography Ophthalmology Humans Medicine medicine.diagnostic_test business.industry Retinal Anatomy Middle Aged medicine.disease Retinal Vein eye diseases medicine.anatomical_structure chemistry Scanning Laser Polarimetry sense organs Tomography business Tomography Optical Coherence Optic disc |
| Zdroj: | Journal of Glaucoma. 19:158-166 |
| ISSN: | 1057-0829 |
| DOI: | 10.1097/ijg.0b013e3181af31ec |
| Popis: | In glaucoma, retinal nerve fiber layer (RNFL) thinning results from progressive loss of retinal ganglion cell (RGC) axons. It is now possible to obtain in vivo measurements of the RNFL thickness. For example, optical coherence tomography (OCT) uses light and interferometry to determine the depth of surfaces differing in reflectance much in the way sonar or ultrasound uses sound.1–4 The commonly used time domain OCT technique measures RNFL thickness along a circular path around the optic disc. Various measures of the resulting RNFL thickness profile can be compared to normative data to determine whether the RNFL is abnormally thin. Measures based upon OCT RNFL thickness generally show good sensitivity and specificity for detecting glaucomatous damage.5–19 However, there is considerable inter-subject variation in the RNFL thickness profiles, even among normal controls. For example, although the RNFL profiles from the two eyes of an individual are very similar,20,21 the profiles differed markedly in both amplitude and waveform across individuals.22 If inter-individual variability can be reduced, it should be possible to improve the sensitivity and specificity of tests based upon OCT RNFL thickness. Recent evidence suggests that the location of the superior and inferior temporal blood vessels (BVs) may account for a portion of the inter-subject variability.22 In particular, the location of the major peaks in the RFNL profiles coincide with the approximate location of the superior and inferior temporal BVs. In part, this is due to the direct contribution of these BVs to RNFL thickness as measured by OCT22–24 and, in part, due to the correlation between the location of these BVs and the location of the arcuate bundles.23 We have previously suggested that adjusting for the location of these BVs might decrease variability among controls.22 In the present study, we tested this hypothesis by adjusting RNFL profiles based upon the position of the superior and inferior temporal BVs. |
| Databáze: | OpenAIRE |
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