Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency
| Autor: | Ken Yasukawa, Yusuke Suzuki, Takehiko Yokomizo, Airi Jo-Watanabe, Toshiaki Okuno, Hyeon-Cheol Lee-Okada, Ryotaro Shioda |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Biophysics Kidney Biochemistry Blood Urea Nitrogen Rats Sprague-Dawley chemistry.chemical_compound Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 medicine Animals Plant Oils Renal Insufficiency Treatment Failure Molecular Biology Blood urea nitrogen Phospholipids chemistry.chemical_classification Creatinine Arachidonic Acid Chemistry alpha-Linolenic Acid Cell Biology Lipid signaling Lipid Metabolism Perilla oil Eicosapentaenoic acid Rats Soybean Oil Endocrinology medicine.anatomical_structure Reperfusion Injury lipids (amino acids peptides and proteins) Arachidonic acid Polyunsaturated fatty acid |
| Zdroj: | Biochemical and Biophysical Research Communications. 582:49-56 |
| ISSN: | 0006-291X |
| Popis: | The efficacy of n-3 polyunsaturated fatty acids (PUFAs) in improving outcomes in a renal ischemia-reperfusion injury (IRI) model has previously been reported. However, the underlying mechanisms remain poorly understood and few reports demonstrate how dietary n-3 PUFAs influence the composition of membrane phospholipids in the kidney. Additionally, it has not been elucidated whether perilla oil (PO), which is mainly composed of the n-3 alpha-linolenic acid, mitigates renal IRI. In this study, we investigated the effect of dietary n-3 PUFAs (PO), compared with an n-6 PUFA-rich soybean oil (SO) diet, on IRI-induced renal insufficiency in a rat model. Levels of membrane phospholipids containing n-3 PUFAs were higher in the kidney of PO-rich diet-fed rats than the SO-rich diet-fed rats. Levels of blood urea nitrogen and serum creatinine were significantly higher in the ischemia-reperfusion group than the sham group under both dietary conditions. However, no significant differences were observed in blood urea nitrogen, serum creatinine, or histological damage between PO-rich diet-fed rats and SO-rich diet-fed rats. In the kidney of PO-rich diet-fed rats, levels of arachidonic acid and arachidonic acid-derived pro-inflammatory lipid mediators were lower than SO-rich diet-fed rats. Eicosapentaenoic acid and eicosapentaenoic acid-derived lipid mediators were significantly higher in the kidney of PO-rich than SO-rich diet-fed rats. These results suggest that dietary n-3 PUFAs alter the fatty acid composition of membrane phospholipids and lipid mediators in the kidney; however, this does not attenuate renal insufficiency or histological damage in a renal IRI model. |
| Databáze: | OpenAIRE |
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