| Autor: |
Amit Maity, Constantinos Koumenis, Nicholas Denko, Sergei A. Vinogradov, Tatiana V. Esipova, Ramon Sun, Alexander Lin, Theresa M. Busch, Stephen Tuttle, Natalie A. Daurio, Shannon M. Gallagher-Colombo, Souvik Dey, George J. Cerniglia |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figures 1-9; Supplementary Table 1. Suppl. Fig. 1 Western blotting for downstream targets of PI3K and mTOR. Suppl. Fig. 2 Effect of dual PI3K/mTOR inhibitors on OCR. Suppl. Fig. 3 Effect of BEZ235 on mitochondrial mass and membrane potential. Suppl. Fig. 4 Analysis of the COX1 DNA levels by RT-PCR. Suppl. Fig. 5 Effect of dual PI3K/mTOR inhibitors on PDH complex subunits. Suppl. Fig. 6 Effects on OCR following the treatment with inhibitors of Akt and/or PI3K. Suppl. Fig. 7 Relationship between PI3K activation and PDH-E1α phosphorylation using doxycycline-inducible system. Suppl. Fig. 8 Effect of PDH-E1α inhibition on OCR. Suppl. Fig. 9 Effect of PDH-E1α mutants on PDH-E1α phosphorylation. Table S1 Sequence of primers used to measure the levels of the COX1 and PNC1. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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