Heat-labile enterotoxin of Escherichia coli promotes intestinal colonization of Salmonella enterica
| Autor: | Alexander Van Parys, Richard Ducatelle, Freddy Haesebrouck, Maryam Atef Yekta, Elin Verbrugghe, Bregje Leyman, Eric Cox, Frank Pasmans, Filip Boyen, Wim Van den Broeck, Sven Arnouts, Urban Lundberg |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Diarrhea
Salmonella typhimurium Salmonella Cell Survival Swine Bacterial Toxins Immunology Enterotoxin Heat-labile enterotoxin medicine.disease_cause Microbiology Cell Line Enterotoxins Enterotoxigenic Escherichia coli medicine Animals Humans Immunology and Allergy Escherichia coli Salmonella Infections Animal Goblet cell General Veterinary biology Escherichia coli Proteins Mucins General Medicine biology.organism_classification Virology Mucus Bacterial Load Intestines Disease Models Animal Enterocytes Jejunum Infectious Diseases medicine.anatomical_structure Salmonella enterica Goblet Cells |
| Zdroj: | Comparative Immunology, Microbiology and Infectious Diseases. 43:1-7 |
| ISSN: | 0147-9571 |
| DOI: | 10.1016/j.cimid.2015.09.002 |
| Popis: | Enterotoxigenic Escherichia coli (ETEC) is an important cause of infantile and travellers' diarrhoea, which poses a serious health burden, especially in developing countries. In addition, ETEC bacteria are a major cause of illness and death in neonatal and recently weaned pigs. The production of a heat-labile enterotoxin (LT) promotes the colonization and pathogenicity of ETEC and may exacerbate co-infections with other enteric pathogens such as Salmonella enterica. We showed that the intraintestinal presence of LT dramatically increased the intestinal Salmonella Typhimurium load in experimentally inoculated pigs. This could not be explained by direct alteration of the invasion or survival capacity of Salmonella in enterocytes, in vitro. However, we demonstrated that LT affects the enteric mucus layer composition in a mucus-secreting goblet cell line by significantly decreasing the expression of mucin 4. The current results show that LT alters the intestinal mucus composition and aggravates a Salmonella Typhimurium infection, which may result in the exacerbation of the diarrhoeal illness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect