Onset of Male Gynaecomastia in a Patient Treated with Sunitinib for Metastatic Renal Cell Carcinoma
| Autor: | Pierluigi Ballardini, Camillo Aliberti, Roberto Manfredini, Guido Margutti |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology medicine.medical_specialty Indoles Erythema medicine.drug_class medicine.medical_treatment Administration Oral Antineoplastic Agents urologic and male genital diseases Vinorelbine Tyrosine-kinase inhibitor Capecitabine Renal cell carcinoma Internal medicine Sunitinib medicine Carcinoma Humans Pyrroles Pharmacology (medical) Carcinoma Renal Cell Protein Kinase Inhibitors Aged business.industry General Medicine medicine.disease Kidney Neoplasms female genital diseases and pregnancy complications Nephrectomy Gynecomastia medicine.symptom business medicine.drug |
| Zdroj: | Clinical Drug Investigation. 29:487-490 |
| ISSN: | 1173-2563 |
| DOI: | 10.2165/00044011-200929070-00007 |
| Popis: | Sunitinib is an orally administered multitargeted tyrosine kinase inhibitor that has demonstrated substantial antitumour activity in patients with metastatic renal cell carcinoma. The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia. We report the case of a 69-year-old patient with metastatic renal clear-cell carcinoma, treated with nephrectomy and three lines of therapy (interleukin-2 plus interferon-alpha2a, vinorelbine plus gemcitabine, and capecitabine), who started a fourth-line therapy with oral sunitinib because of disease progression. At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema. After 2 weeks' off therapy, a partial reduction in mammary gland enlargement, local pain and erythema was observed. However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again. The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors. To the best of our knowledge, this is the first report of an association between sunitinib and gynaecomastia. |
| Databáze: | OpenAIRE |
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