Circulating chaperones in patients with aortic valve stenosis undergoing TAVR: impact of concomitant chronic kidney disease

Autor: Jan-Malte Sinning, Felix Jansen, Adem Aksoy, Marc Ulrich Becher, Baravan Al-Kassou, Georg Nickenig, Hendrik Treede, Muntadher Al Zaidi, Sebastian Zimmer, Alexander Sedaghat, J. Shamekhi, Vedat Tiyerili, Elena Repges
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Kaplan-Meier Estimate
Cohort Studies
Transcatheter Aortic Valve Replacement
Translational Research
Biomedical
03 medical and health sciences
0302 clinical medicine
Valve replacement
Risk Factors
Physiology (medical)
Internal medicine
medicine
Humans
Renal Insufficiency
Chronic
Endoplasmic Reticulum Chaperone BiP
Heat-Shock Proteins
Aged
Aged
80 and over
Univariate analysis
business.industry
Mortality rate
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Aortic Valve Stenosis
General Medicine
Prognosis
medicine.disease
Comorbidity
030104 developmental biology
030220 oncology & carcinogenesis
Concomitant
Aortic valve stenosis
Cardiology
Female
business
Biomarkers
Molecular Chaperones
Kidney disease
Cohort study
Zdroj: Translational Research. 233:117-126
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2021.03.003
Popis: Chronic kidney disease (CKD) is a frequent comorbidity of aortic valve stenosis (AVS). Circulating chaperones have emerged as both effectors and prognostic markers for various diseases. We investigated the role of circulating chaperones in patients with severe AVS undergoing transcatheter aortic valve replacement (TAVR). In this observational cohort study, 159 consecutive patients undergoing TAVR were included and serum levels of Glucose-regulated protein 78 (GRP78) and heat shock protein 27 (HSP27) were measured by ELISA. The primary end point was defined as 1-year mortality. Patients with lower levels of circulating GRP78 (
Databáze: OpenAIRE
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