The Influence of Various Cerebral and Extracerebral Pathologies on Apparent Diffusion Coefficient Values in the Fetal Brain
| Autor: | Luigi Raio, Roland Wiest, Manuela Pastore-Wapp, Nadja Schönberg, Eike I. Piechowiak, Harald M. Bonel, Jennifer L. Cullmann, Nedelina Slavova, Christian Weisstanner |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty brain Ischemia Gestational Age 610 Medicine & health 030218 nuclear medicine & medical imaging Fetal Development White matter 03 medical and health sciences 0302 clinical medicine fetal MRI medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Retrospective Studies Original Research Fetus maturation business.industry Gestational age medicine.disease Magnetic Resonance Imaging Pons Hydrocephalus Stroke body regions Diffusion Magnetic Resonance Imaging medicine.anatomical_structure ADC Clinical Investigative Study cerebral pathologies Neurology (clinical) business 150 Psychology 030217 neurology & neurosurgery Ventriculomegaly |
| Zdroj: | Schönberg, Nadja; Weisstanner, Christian; Wiest, Roland; Bonél, Harald M.; Piechowiak, Eike I.; Cullmann, Jennifer L.; Raio, Luigi; Pastore-Wapp, Manuela; Slavova, Nedelina (2020). The Influence of Various Cerebral and Extracerebral Pathologies on Apparent Diffusion Coefficient Values in the Fetal Brain. Journal of neuroimaging, 30(4), pp. 477-485. Wiley 10.1111/jon.12727 Journal of Neuroimaging |
| DOI: | 10.1111/jon.12727 |
| Popis: | BACKGROUND AND PURPOSE: The changing MRI signal accompanying brain maturation in fetal brains can be quantified on apparent diffusion coefficient (ADC) maps. Deviations from the natural course of ADC values may reflect structural pathology. The purpose of this study was to determine the influence of fetal pathologies on the ADC values in different regions of the fetal brain and their evolution with increasing gestational age. METHODS: This was a retrospective study of 291 fetuses evaluated between the 14th and the 40th week of gestation using diffusion-weighted imaging (DWI). Fetuses with normal MRI findings but sonographically suspected pathology or fetuses with abnormalities not affecting the brain were analyzed in the control group and compared to fetuses suffering from different pathologies like hydrocephalus/ventriculomegaly, brain malformations, infections, ischemia/hemorrhage, diaphragmatic hernias, and congenital heart disease. Pairwise ADC measurements in each side of the white matter (WM) of the frontal, parietal, and occipital lobes, in the basal ganglia and the cerebellum, as well as a single measurement in the pons were performed and were plotted against gestational age. RESULTS: In the control group, brain maturation followed a defined gradient, resulting in lower ADC values in the most mature regions. Each disorder group experienced abnormal patterns of evolution of the ADC values over time deviating from the expected course. CONCLUSIONS: The ADC values in different regions of the fetal brain and their evolution with increasing gestational age are influenced by pathologies compromising the cerebral maturation. |
| Databáze: | OpenAIRE |
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