Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
| Autor: | Marta Garcés-Rimón, Visitación López-Miranda, Esperanza Herradón, Cristina González, Raquel Hernanz, María J. Alonso, J. A. Uranga, Marta Miguel, Roberto Palacios, Angela Martín |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Garcés Rimón, M., Garcés Rimón, M. [0000-0002-3888-4150] |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Antioxidant 030309 nutrition & dietetics Protein Hydrolysates medicine.medical_treatment Biophysics Blood Pressure medicine.disease_cause Antioxidants 03 medical and health sciences 0404 agricultural biotechnology Egg White Internal medicine medicine.artery medicine Animals Obesity Endothelial dysfunction Aorta Pharmacology 0303 health sciences Kidney business.industry 04 agricultural and veterinary sciences Cell Biology Egg white proteins medicine.disease 040401 food science Metabolic syndrome Zucker rats Mesenteric Arteries Rats Rats Zucker Oxidative Stress Blood pressure Endocrinology medicine.anatomical_structure Cardiovascular diseases Enzymatic hydrolysis business Oxidative stress Food Science Egg white |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium‐emitted fluorescence, NOX‐1 mRNA levels by qRT‐PCR, angiotensin‐converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress. Ministerio de Ciencia, Innovación y Universidades, Grant/Award Number: AGL2012‐32387 and SAF2015‐69294‐R |
| Databáze: | OpenAIRE |
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