Interferon receptors and their role in interferon action
| Autor: | Sidney E. Grossberg, J. L. Taylor, V. M. Kushnaryov |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pharmacology
Janus kinase 1 Class C GPCR Cell Biology Immune receptor Biology Models Biological Cell biology Cellular and Molecular Neuroscience Chemokine receptor Interferon-gamma Interferon Type I Molecular Medicine Animals Humans Protease-activated receptor Signal transduction Cloning Molecular Receptors Immunologic Receptor Molecular Biology PELP-1 Receptors Interferon |
| Zdroj: | Experientia. 45(6) |
| ISSN: | 0014-4754 |
| Popis: | Interferon (IFN)_proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of different kinds of cells but in relatively low numbers (102–104/cell). The relationship between IFN binding to receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|