IL-2-dependent generation of natural killer cells from bone marrow: Role of MAC-1−, NK1-1− precursors
| Autor: | Carlo Riccardi, Graziella Migliorati, Ildo Nicoletti, R. Moraca |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Male CD3 Complex Cellular differentiation Immunology Receptors Antigen T-Cell Macrophage-1 Antigen Bone Marrow Cells Biology Natural killer cell Mice Interleukin 21 Bone Marrow Tumor Cells Cultured medicine Animals Antigens Ly Lectins C-Type Antigens Lymphokine-activated killer cell Proteins Cell Differentiation Hematopoietic Stem Cells Natural killer T cell Cell biology Killer Cells Natural Natural Killer Cells medicine.anatomical_structure Antigens Surface Interleukin 12 Interleukin-2 Female Bone marrow Stem cell NK Cell Lectin-Like Receptor Subfamily B |
| Zdroj: | Cellular Immunology. 141:323-331 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/0008-8749(92)90151-e |
| Popis: | We have previously shown that interleukin-2 (IL-2) is able to induce the generation of natural killer (NK) activity in bone marrow (BM) cell cultures from mice pretreated with 5-fluorouracil (5-FU). Cell fractionation experiments to analyze the nature of BM precursors indicate that MAC-1 − , NK1-1 − noncytotoxic precursors are induced by IL-2 to proliferate and generate cytolytic NK cells. These data demonstrate that the phenotype and functional characteristics of the IL-2-responsive cells in the FUBM are different from those of mature NK cells in that they are MAC-1 + , NK1.1 + , CD3 − and susceptible to boosting by IFN-α. |
| Databáze: | OpenAIRE |
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