Effects of post-training modafinil administration in a discriminative avoidance task in mice
| Autor: | Karina A. Zanin, Lia Bittencourt, Leonardo B. Lopes-Silva, C.S. Bizerra, Roberto Frussa-Filho, Camilla L. Patti, H.A. Fernandes, Sergio Tufik |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Modafinil Anxiety Task (project management) Discrimination Learning Mice Memory Post training Avoidance Learning Medicine Animals Benzhydryl Compounds Maze Learning Biological Psychiatry Memory Disorders Dose-Response Relationship Drug business.industry Wakefulness-Promoting Agents Impaired memory Psychiatry and Mental health Disease Models Animal Anesthesia Memory consolidation medicine.symptom business medicine.drug |
| Zdroj: | Acta neuropsychiatrica. 27(4) |
| ISSN: | 1601-5215 0924-2708 |
| Popis: | ObjectiveAlthough the cognitive-enhancing abilities after modafinil have been demonstrated, its effects on memory consolidation remain overlooked. We investigated the effects of repeated modafinil administration on consolidation of a discriminative avoidance task.MethodsMice were trained in the plus-maze discriminative avoidance task. After training, mice received intraperitonial modafinil (doses of 32, 64 or 128 mg/kg). Animals were treated for more 9 consecutive days; 30 min after the last injection, testing was performed. In addition, the effects of 32 mg/kg modafinil on consolidation at different time points were examined.ResultsThe smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion. Still, modafinil post-training administration at 1 or 2 h impaired memory persistence.ConclusionsModafinil impaired memory consolidation in a dose- and time-dependent fashion. |
| Databáze: | OpenAIRE |
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