FeCl3-Mediated Side Chain Modification of Aspartic Acid- and Glutamic Acid-Containing Peptides on a Solid Support
| Autor: | Srinivasa Rao Manne, Bhubaneswar Mandal, Ashim Paul, Gobinda Dolai, Rajat Subhra Giri, Tapasi Kalita |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry General Chemical Engineering Fmoc chemistry Peptide General Chemistry Glutamic acid 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences lcsh:Chemistry lcsh:QD1-999 chemistry Yield (chemistry) Aspartic acid Posttranslational modification Side chain Organic chemistry Lewis acids and bases |
| Zdroj: | ACS Omega, Vol 2, Iss 10, Pp 6586-6597 (2017) |
| ISSN: | 2470-1343 |
| DOI: | 10.1021/acsomega.7b01143 |
| Popis: | An efficient, convenient, and selective Lewis acid-based strategy for on-resin deprotection of the side chain tert-butyl-protected aspartic acid and glutamic acid of a peptide is achieved. The method is mild, cost-effective, and Fmoc chemistry compatible and allows on-resin incorporation of amides, esters, and thioesters in good yield. This method will find wide applicability in peptide and protein modification because it enriches the toolbox of orthogonal protection/deprotection techniques. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|