Possible lack of association between E469K polymorphism of ICAM-1 and non-obstructive azoospermia in south-east Turkey

Autor: Aydin Rustemoglu, Necmettin Penbegül, Halit Akbas, Mahmut Balkan, İlyas Yücel, İsmail Yıldız
Rok vydání: 2016
Předmět:
Zdroj: Biotechnology & Biotechnological Equipment, Vol 31, Iss 1, Pp 143-147 (2017)
ISSN: 1314-3530
1310-2818
DOI: 10.1080/13102818.2016.1261635
Popis: WOS:000390379500020 Intercellular adhesion molecule-1 (ICAM-1), a member of the large immunoglobulin superfamily of cell adhesion molecules, is a constituent component of the blood-testis barrier, and it plays a significant role in the homeostasis of spermatogenesis. The E469K polymorphism in the human ICAM-1 gene has been previously associated in various inflammatory/autoimmune disorders. However, the role of the ICAM-1 E469K polymorphism in spermatogenesis remains unclear. The aim of the present study is to analyse the possible association between the ICAM-1 E469K polymorphism and male infertility with non-obstructive azoospermia (NOA) patients within a group of men from Turkey. We included 111 infertile male with NOA and 114 fertile male as control subjects to the study. Genotyping was made by polymerase chain reaction-restriction fragment length polymorphism. The frequency of the genotype and the allele of ICAM-1 E469K were not significantly different between the control group and the patients (P > 0.05). This is the first study to investigate the role of the ICAM-1 gene polymorphism in male infertility with NOA. We conclude that the E469K polymorphism of ICAM-1 is not a risk factor for NOA in the Turkish population.
Databáze: OpenAIRE
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