Wacker‐Type Oxidation Using an Iron Catalyst and Ambient Air: Application to Late‐Stage Oxidation of Complex Molecules

Autor:	Binbin Liu, Xiaorong Yuan, Fengli Jin, Wei Han, Tianjiao Wang
Rok vydání:	2017
Předmět:	chemistry.chemical_classification Polymethylhydrosiloxane Ketone Alkene 010405 organic chemistry Radical General Chemistry General Medicine 010402 general chemistry Chloride 01 natural sciences Catalysis 0104 chemical sciences Wacker process chemistry.chemical_compound chemistry Reagent medicine Organic chemistry Molecule medicine.drug
Zdroj:	Angewandte Chemie. 129:12886-12891
ISSN:	1521-3757 0044-8249
DOI:	10.1002/ange.201707006
Popis:	A practical and general iron-catalyzed Wacker-type oxidation of olefins to ketones is presented, and it uses ambient air as the sole oxidant. The mild oxidation conditions enable exceptional functional-group tolerance, which has not been demonstrated for any other Wacker-type reaction to date. The inexpensive and nontoxic reagents [iron(II) chloride, polymethylhydrosiloxane, and air] can, therefore, also be employed to oxidize complex natural-product-derived and polyfunctionalized molecules.
Databáze:	OpenAIRE
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