Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig
| Autor: | M.-N. Horcajada, Membrez Scalfo, Christelle Sanchez, Fanny Comblain, Elizabeth A. Offord, Sébastien Taralla, Pierre Drion, Anne-Françoise Donneau, Yves Henrotin |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Curcumin Rutin Guinea Pigs Iridoid Glucosides Biomedical Engineering Osteoarthritis Guinea pig chemistry.chemical_compound Rheumatology Oleuropein Internal medicine Synovitis medicine Animals Iridoids Orthopedics and Sports Medicine 2. Zero hunger business.industry Cartilage medicine.disease 3. Good health Surgery Endocrinology medicine.anatomical_structure chemistry Hartley Guinea Pig Phytonutrients Synovial membrane business Biomarkers |
| Zdroj: | Osteoarthritis and Cartilage. 23(1):94-102 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2014.08.016 |
| Popis: | SummaryObjectiveTo assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development.DesignSixty 4-week-old Dunkin–Hartley guinea pigs were randomized into four groups and received daily during 31 weeks either standard guinea pig diet (control group) or a standard guinea pig diet enriched with oleuropein (0.025%), rutin (0.5%) or rutin/curcumin (0.5%/0.25%) association. Biomarkers of OA (Coll2-1, Coll2-1NO2, Fib3-1, Fib3-2, ARGS), as well as inflammation prostaglandin E2 (PGE2) were quantified in the serum. Histological assessments of knee cartilage and synovial membrane were performed at week 4 (five young reference guinea pigs) and week 35.ResultsAt week 35, guinea pigs in the control group spontaneously developed significant cartilage lesions with mild synovial inflammation. The histological scores of cartilage lesions and synovitis were well correlated with the increased level of serum biomarkers. Histologically, all treatments significantly reduced the cartilage degradation score (P |
| Databáze: | OpenAIRE |
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