The effects of Helicobacter pylori eradication therapy on salivary pepsin concentration in patients with laryngopharyngeal reflux

Autor: Qing-Qing Zhang, Meng Xie, Rui-Xin Guo, Xiao-Hong Liu, Si-Jing Ma, null Na Li, Yang-Juan Chen, Min-Juan Yang, Ye-Wen Shi, Xiao-Yong Ren, Hua-Nan Luo
Rok vydání: 2022
Předmět:
Zdroj: European Archives of Oto-Rhino-Laryngology. 279:5289-5297
ISSN: 1434-4726
0937-4477
DOI: 10.1007/s00405-022-07439-y
Popis: To investigate the effect of Helicobacter pylori (HP) eradication therapy on salivary pepsin concentration in laryngopharyngeal reflux (LPR) patients with HP infection.A total of 477 patients with suspected LPR were enrolled from June 2020 to September 2021. Reflux symptom index, reflux finding score, the positive rates and disintegrations per minute values of HP infection detected byThe scores of nagging cough (0.88 vs. 0.50, P = 0.035), erythema or hyperemia (1.93 vs. 1.78, P = 0.035) and vocal fold edema (1.04 vs. 0.85, P = 0.025) were higher in the LPR (+) Hp (+) subgroup than in LPR (+) Hp (-) subgroup. The concentrations of salivary pepsin in the Hp (+) subgroup were higher than in the Hp (-) subgroup either in LPR patients (75.24 ng/ml vs. 61.39 ng/ml, P = 0.005) or the non-LPR patients (78.42 ng/ml vs. 48.96 ng/ml, P = 0.024). Compared to baseline (before treatment), scores of nagging cough (0.35 vs. 0.84, P = 0.019) and erythema or hyperemia (1.50 vs. 1.83, P = 0.039) and the concentrations of salivary pepsin (44.35 ng/ml vs. 74.15 ng/ml, P = 0.017) in LPR patients with HP infection decreased after HP treatment; yet, this was not observed for the LPR patients without HP infection treated with PPI only (P 0.05).HP infection may aggravate the symptoms and signs of LPR patients, partly by increasing their salivary pepsin concentration.
Databáze: OpenAIRE
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