Survival benefit of accepting kidneys from older donation after cardiac death donors
| Autor: | Jacqueline Garonzik-Wang, Allan B. Massie, Jane J. Long, Mary G. Bowring, Sile Yu, Jennifer D. Motter, Dorry L. Segev, Niraj M. Desai, Tanveen Ishaque, Yifan Yu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Tissue and Organ Procurement 030230 surgery Kidney Living donor Article Donor Selection 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Humans Immunology and Allergy Pharmacology (medical) Registries Kidney transplantation Transplantation business.industry Graft Survival Hazard ratio Donation after cardiac death Middle Aged medicine.disease Tissue Donors Death Survival benefit medicine.anatomical_structure business |
| Zdroj: | Am J Transplant |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/ajt.16198 |
| Popis: | Kidneys from older (age ≥50 years) donation after cardiac death (DCD50) donors are less likely to be transplanted due to inferior posttransplant outcomes. However, candidates who decline a DCD50 offer must wait for an uncertain future offer. To characterize the survival benefit of accepting DCD50 kidneys, we used 2010-2018 Scientific Registry for Transplant Recipients (SRTR) data to identify 92 081 adult kidney transplantation candidates who were offered a DCD50 kidney that was eventually accepted for transplantation. DCD50 kidneys offered to candidates increased from 590 in 2010 to 1441 in 2018. However, 34.6% of DCD50 kidneys were discarded. Candidates who accepted DCD50 offers had 49% decreased mortality risk (adjusted hazard ratio [aHR] 0.46 0.510.55 , cumulative mortality at 6-year 23.3% vs 34.0%, P |
| Databáze: | OpenAIRE |
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