Functional divergence of the MAP kinase pathway ERK1 and ERK2 activate specific transcription factors

Autor: Chiou-Fen Chuang, Sun-Yu Ng
Rok vydání: 1994
Předmět:
DNA
Complementary
Transcription
Genetic
Retroviridae Proteins
Oncogenic
MAPK7
Moloney murine sarcoma virus
Biophysics
Gene Expression
Myc
Protein Serine-Threonine Kinases
Mitogen-activated protein kinase kinase
Transfection
Biochemistry
ERK1
ERK2
MAP2K7
Proto-Oncogene Proteins c-myc
Mice
Elk-1
Structural Biology
Proto-Oncogene Proteins
Genetics
Animals
Humans
ASK1
c-Raf
Phosphorylation
Promoter Regions
Genetic
Molecular Biology
Repetitive Sequences
Nucleic Acid
ets-Domain Protein Elk-1
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
MAP kinase kinase kinase
Chemistry
MAPKAPK2
3T3 Cells
Cell Biology
Protein-Tyrosine Kinases
Molecular biology
Rats
DNA-Binding Proteins
Calcium-Calmodulin-Dependent Protein Kinases
MAP kinase
Metallothionein
Cyclin-dependent kinase 9
Mitogen-Activated Protein Kinases
Plasmids
Signal Transduction
Transcription Factors
Zdroj: FEBS Letters. 346:229-234
ISSN: 0014-5793
Popis: Growth factor—receptor interactions at the cell surface eventually leading to the transcriptional activation of immediate early genes is mediated by the mitogen-activated protein kinase (MAP kinase/MAPK) cascade. Here we show that overexpression of extracellular signal-regulated kinase 1 (ERK1) cDNA, encoding p44mapk, results in the activation of Elk-1, the serum response factor accessory protein. We also show that overexpression of ERK2, encoding p42mapk, activates Myc, but not Elk-1. Therefore, the MAP kinase cascade diverges with at least one specific target for each MAP kinase isoform and provides a novel mechanism for differential regulation of this signaling pathway.
Databáze: OpenAIRE
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