Early Amplitude-Integrated Electroencephalogram as a Predictor of Brain Injury in Newborns With Very Low Birth Weight: A Cohort Study
| Autor: | Renato S. Procianoy, José Augusto Bragatti, Maria Isabel Bragatti Winckler, Luiza V S Magalhães, Rita de Cássia dos Santos Silveira |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Birth weight Electroencephalography Likelihood ratios in diagnostic testing Cohort Studies 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine medicine Humans Infant Very Low Birth Weight Ultrasonography medicine.diagnostic_test business.industry Infant Newborn Magnetic resonance imaging Magnetic Resonance Imaging Amplitude integrated electroencephalography Low birth weight Brain Injuries Pediatrics Perinatology and Child Health Cardiology Female Neurology (clinical) Analysis of variance medicine.symptom business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Journal of child neurology. 33(10) |
| ISSN: | 1708-8283 |
| Popis: | Purpose: To evaluate the relationship between abnormal early amplitude integrated electroencephalography (EEG) and severe lesions in imaging tests performed during the neonatal period in very low birth weight infants. Methods: An amplitude-integrated EEG was performed in 70 patients with a mean birth weight of 1226 g during the first 48 hours of life. Severe lesions on magnetic resonance imaging (MRI) or ultrasonography (US) during the neonatal period were considered as adverse conditions. Variables were compared using the χ2 test or analysis of variance. Sensitivity, specificity, and positive likelihood ratio were calculated. Results: Adverse outcomes were observed in 6 patients. There was a significant relationship ( P < .001) between abnormal amplitude-integrated EEG background and severe lesions on MRI and US. Sensitivity and specificity were 100% and 89%, respectively. Conclusion: Early amplitude-integrated EEG with moderate/severe abnormalities in the background is associated with severe structural lesions detected in imaging studies and should be considered as an auxiliary screening tool for the detection of neonatal brain lesions in very low birth weight infants. |
| Databáze: | OpenAIRE |
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