Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression
| Autor: | Lilian Koh Hui Li, Neha Khandelwal, Vikram Nakhate, Padmamalini Mahendradas, Rupesh Agrawal |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Vogt–Koyanagi–Harada disease medicine.medical_specialty Pathology genetic structures Indocyanine green angiography Biomedical Engineering Fundus (eye) 03 medical and health sciences 0302 clinical medicine Vascularity Optical coherence tomography image analysis Ophthalmology medicine optical coherence tomography medicine.diagnostic_test business.industry Disease progression Articles medicine.disease eye diseases 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry sense organs Choroid Enhanced depth imaging medicine.symptom business choroid Vogt-Koyanagi-Harada disease |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose We assessed the application of the choroidal vascularity index (CVI) in the follow-up of Vogt-Koyanagi-Harada disease (VKH) patients derived from image binarization of enhanced depth imaging optical coherence tomography (EDI-OCT) images with Fiji software. Our secondary objective was to derive the retinochoroidal vascularity index based on en face fundus fluorescein and indocyanine green angiography (FFA and ICGA). Methods In this retrospective cohort study, EDI-OCT scans of 18 eyes of 9 patients with VKH were obtained at baseline within 2 weeks of acute presentation, and again at 6 to 12 months. Images with poor quality were excluded. Choroidal thickness (CT) and CVI were analyzed and compared to 13 eyes of 13 healthy controls. En face FFA and ICGA obtained from 12 eyes of 7 patients were segmented to derive retinochoroidal vascularity index. Results There was no statistical difference in age or sex between the study group and controls. Choroidal thickness of patients with VKH was 359.23 ± 57.63 μm at baseline, compared to 274.09 ± 56.98 μm in controls (P = 0.003). Follow-up CT in VKH patients was 282.62 ± 42.51 μm, which was significantly decreased from baseline (P = 0.0001). Choroidal vascularity index in VKH patients was 70.03 ± 1.93% at baseline, compared to 64.63 ± 1.92% in controls (P < 0.001). Choroidal vascularity index was 66.94 ± 1.82% at follow-up, significantly reduced from baseline (P < 0.0001). Fundus fluorescein angiography and ICGA retinochoroidal vascularity indices at baseline were 70.67 ± 2.65% and 66.42 ± 2.16%, respectively. Conclusions In this small series of VKH patients, EDI-OCT–derived CVI had a statistically significant reduction over time, similar to CT. We propose that OCT, FFA, and ICGA-derived vascularity indices may be potential novel supportive tools in monitoring disease progression in VKH. Translational Relevance Choroidal vascularity index can be used potentially to study and analyze the structural changes in choroid. It can be a useful tool to explain the changes in the CT in different retinochoroidal disorders. Choroidal vascularity index also can be used for longitudinal follow-up in patients with VKH disease and other inflammatory disease involving the choroid. |
| Databáze: | OpenAIRE |
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