Nickel(0)-catalyzed intramolecular reductive coupling of alkenes and aldehydes or ketones with hydrosilanes
| Autor: | Yukari Hayashi, Ravindra Kumar, Masato Ohashi, Sensuke Ogoshi, Yoichi Hoshimoto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Alkene Metals and Alloys chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Aldehyde Catalysis Coupling reaction 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Nickel chemistry Intramolecular force Materials Chemistry Ceramics and Composites Organic chemistry Triethylsilane Carbene |
| Zdroj: | Chemical communications (Cambridge, England). 52(37) |
| ISSN: | 1364-548X |
| Popis: | A nickel(0)-catalyzed reductive coupling of aldehydes and simple alkenes with hydrosilanes has been developed. A variety of silyl-protected 1-indanol derivatives were prepared in a highly diastereoselective manner (up to >99 : 1 dr) by employing a combination of nickel(0)/N-heterocyclic carbene and triethylsilane. The present system was also applied to a reductive coupling with ketones. Preliminary results of a nickel(0)-catalyzed asymmetric three-component coupling reaction of an aldehyde, an alkene, and triethylsilane are also shown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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