Potential of [18F]-Fluoromisonidazole positron-emission tomography for radiotherapy planning in head and neck squamous cell carcinomas
| Autor: | Philippe Fernandez, Thibaut Merlin, B. Henriques de Figueiredo, Frederic Lamare, H. De Clermont-Gallerande, Delphine Vimont, Mathieu Hatt |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty 18F-Fluoromisonidazole medicine.medical_treatment Computed tomography Sensitivity and Specificity medicine Humans Radiology Nuclear Medicine and imaging Misonidazole Head and neck Aged medicine.diagnostic_test Squamous Cell Carcinoma of Head and Neck business.industry Radiotherapy Planning Computer-Assisted Reproducibility of Results Image segmentation Middle Aged Prognosis Tumor Burden Radiation therapy Treatment Outcome Oncology Head and Neck Neoplasms Positron emission tomography Positron-Emission Tomography Carcinoma Squamous Cell Feasibility Studies Female Tomography Radiology Radiopharmaceuticals Nuclear medicine business FMISO Radiotherapy Image-Guided |
| Zdroj: | Strahlentherapie und Onkologie. 189:1015-1019 |
| ISSN: | 1439-099X 0179-7158 |
| Popis: | Positron-emission tomography (PET) with [(18)F]-fluoromisonidazole (FMISO) permits consideration of radiotherapy dose escalation to hypoxic volumes in head and neck cancers (HNC). However, the definition of FMISO volumes remains problematic. The aims of this study are to confirm that delayed acquisition at 4 h is most appropriate for FMISO-PET imaging and to assess different methods of volume segmentation.A total of 15 HNC patients underwent several FMISO-PET/computed tomography (CT) acquisitions 2, 3 and 4 h after FMISO injection. Three automatic methods of PET image segmentation were tested: fixed threshold, adaptive threshold based on the ratio between tumour-derived and background activities (R(T/B)) and the fuzzy locally adaptive Bayesian (FLAB) method. The hypoxic fraction (HF), which is defined as the ratio between the FMISO and CT volumes, was also calculated.The R(T/B) for images acquired at 2, 3 and 4 h differed significantly, with mean values of 2.5 (1.7-2.9), 3 (2-4.5) and 3.4 (2.3-6.1), respectively. The mean tumour volume, as defined manually using CT images, was 39.1 ml (1.2-116 ml). After 4 h, the mean FMISO volumes were 18.9 (0.1-81), 9.5 (0.9-33.1) and 12.5 ml (0.9-38.4 ml) with fixed threshold, adaptive threshold and the FLAB method, respectively; median HF values were 0.47 (0.1-1.93), 0.25 (0.11-0.75) and 0.35 (0.14-1.05), respectively. FMISO volumes were significantly different.The best contrast is obtained at the 4-hour acquisition time. Large discrepancies were found between the three tested methods of volume segmentation. |
| Databáze: | OpenAIRE |
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