Cirrhosis Associated with the Australia Antigen in an Infant Who Acquired Hepatitis from Her Mother
| Autor: | B. D. Bower, J. R. Perkins, Ralph Wright, D. W. Jerrome |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Liver Cirrhosis
Hepatitis B virus Immunodiffusion Pathology medicine.medical_specialty Cirrhosis Biopsy Hepatosplenomegaly Jaundice Hepatitis B Antigens Liver Function Tests Pregnancy medicine Humans Pregnancy Complications Infectious General Environmental Science Hepatitis medicine.diagnostic_test business.industry General Engineering Infant Hepatitis A Papers and Originals General Medicine Orthomyxoviridae medicine.disease Microscopy Electron Blood Liver Liver biopsy Acute Disease Carrier State Chronic Disease Splenomegaly General Earth and Planetary Sciences Female Liver function medicine.symptom Viral hepatitis business Hepatomegaly |
| Zdroj: | BMJ. 4:719-721 |
| ISSN: | 1468-5833 0959-8138 |
| Popis: | A 19-week-old English girl developed acute viral hepatitis, which became chronic with persistent hepatosplenomegaly and abnormal liver function tests. Liver biopsy at 1 year showed an active cirrhosis with multinucleated giant cells. The Australia (Au) antigen was detected repeatedly in the infant's serum by immunodiffusion and by electron microscopy at the time of the acute attack and during the development of cirrhosis. She had apparently acquired the hepatitis from her mother, who had had jaundice at the end of pregnancy and for one month thereafter, and who was subsequently shown to be a carrier of Au antigen. Particles with surface projections resembling paramyxoviruses were observed in two of the later specimens of the infant's serum. |
| Databáze: | OpenAIRE |
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