Damage in Mitochondrial DNA Associated with Parkinson's Disease
| Autor: | Olivier Lurette, Rebeca Martín-Jiménez, Etienne Hebert-Chatelain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA Programmed cell death Parkinson's disease Disease Mitochondrion Biology DNA Mitochondrial 03 medical and health sciences 0302 clinical medicine Organelle Genetics medicine Animals Humans Molecular Biology Neurons Parkinson Disease Cell Biology General Medicine medicine.disease Mitochondria 030104 developmental biology 030220 oncology & carcinogenesis Models Animal Homeostasis DNA Damage Human mitochondrial DNA haplogroup |
| Zdroj: | DNA and Cell Biology. 39:1421-1430 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2020.5398 |
| Popis: | Mitochondria are the only organelles that contain their own genetic material (mtDNA). Mitochondria are involved in several key physiological functions, including ATP production, Ca2+ homeostasis, and metabolism of neurotransmitters. Since these organelles perform crucial processes to maintain neuronal homeostasis, mitochondrial dysfunctions can lead to various neurodegenerative diseases. Several mitochondrial proteins involved in ATP production are encoded by mtDNA. Thus, any mtDNA alteration can ultimately lead to mitochondrial dysfunction and cell death. Accumulation of mutations, deletions, and rearrangements in mtDNA has been observed in animal models and patients suffering from Parkinson's disease (PD). Also, specific inherited variations associated with mtDNA genetic groups (known as mtDNA haplogroups) are associated with lower or higher risk of developing PD. Consequently, mtDNA alterations should now be considered important hallmarks of this neurodegenerative disease. This review provides an update about the role of mtDNA alterations in the physiopathology of PD. |
| Databáze: | OpenAIRE |
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